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《医学前沿(英文)》 页码 1006-1009 doi: 10.1007/s11684-023-1000-3
关键词: family craniofacial microsomia Identification novel mutations
Epidemiological study of a von Hippel-Lindau family in northwest China
null
《医学前沿(英文)》 2013年 第7卷 第3期 页码 378-385 doi: 10.1007/s11684-013-0276-0
von Hippel-Lindau (VHL) disease is a rare, inherited neoplastic disease characterized by hemangioblastomas (HBL) of the central nervous system (CNS), retinal angiomas, renal cell carcinomas (RCC), pancreatic endocrine tumors (PETs), pheochromocytomas, paragangliomas, and visceral cysts. We encountered a large VHL family in northwest China and conducted a systematic screening of the family members based on their epidemiological and clinical characteristics. A self-designed questionnaire was used to collect the general sociodemographic and health information of the family members. For the preliminary family screening, physical examination and abdomen B ultrasonography were performed. The suspected patients were subjected to cranial computerized tomography and fundus examination. The clinical data of the patients with confirmed VHL disease were collected from hospital records. A total of 63 lineal descendants in six generations were observed in the family (generations O, A, B, C, D, E), including 9 dead suspected cases (6 males, 3 females) and 10 living cases (2 males, 8 females). Among the 10 living cases, 4, 2, 1, 3, 4, 8, and 2 manifested HBLs of the CNS, PETs, RCC, pancreatic cysts, renal cysts, pheochromocytomas (4 hemi and 4 bilateral), and paragangliomas, respectively. Data showed that the morbidity of VHL disease in generation C was lower than that in generation B, but the age of onset was younger. This study is the first to report VHL disease in northwest China and VHL-associated PET cases in Chinese. Therefore, follow-up checkups of the family should be focused on younger generations. Proper family screening protocols should be followed for the treatment of patients with VHL disease.
关键词: von Hippel-Lindau disease epidemiology family screening pancreatic endocrine tumor
朵英贤
《中国工程科学》 1999年 第1卷 第2期 页码 57-61
主要叙述我国轻武器行业两代工程技术人员在基础很薄弱的情况下,团结合作,用科学和严密的方法,在很短的时间内研制出高水平的步兵班用枪族,使中国步兵枪械达到世界先进水平,受到军方高度评价。该枪族已于1997年元月正式装备驻港部队,并将陆续装备全军。
Family planning technical services in China
Shang-Chun WU
《医学前沿(英文)》 2010年 第4卷 第3期 页码 285-289 doi: 10.1007/s11684-010-0097-3
严小青
《中国工程科学》 2014年 第16卷 第5期 页码 24-30
通过选取杭州市上城区社区卫生院109 例婴儿及其母亲为调查对象,利用SPSS18.0 软件分别从一般参考量、影响喂养方式相关性因素以及基层计生优质服务需求进行数据统计分析,从而得到影响母乳喂养因素、喂养方式与婴儿体格关系以及服务需求重点,从而提出要从卫生计生联手、育医结合,立足基层架构群众满意服务网络;探索途径、优化服务,实现流动人口优质服务一盘棋;强化队伍、创新机制,探索建立科学规范服务考核评估体系三方面全面提升新时期基层计生优质服务水平。
SUPEROXIDE DISMUTASE FAMILY GENES IN WATERMELON AND THEIR RESPONSES TO DIFFERENT ABIOTIC STRESSES
《农业科学与工程前沿(英文)》 2021年 第8卷 第4期 页码 645-658 doi: 10.15302/J-FASE -2020350
Superoxide dismutase (SOD) is an important enzyme in the antioxidant system of plants and plays a vital role in stress responses by maintaining the dynamic balance of reactive oxygen species (ROS) concentrations. Genome-wide analysis of the SOD gene family in various plant species has been conducted but little is known about this gene family in watermelon (Citrullus lanatus). Here, eight SOD genes were identified in the watermelon genome and are designated ClCSD1-5, ClFSD1-2 and ClMSD according to their metal cofactors. Phylogenetic analysis shows that SOD proteins from various plant species can be classified into five groups and members in the same group possess the same metal cofactor and similar subcellular localizations. Expression analysis of the ClSOD genes indicates that they had tissue-specific expression patterns with high expression in different tissues including the leaves, flowers and fruit. In addition, the expression of ClSOD genes differed appreciably under salinity, drought and abscisic acid (ABA) treatments, indicating that they may be involved in ROS scavenging under different abiotic stresses via an ABA-dependent signaling pathway. These results lay the foundation for elucidating the function of ClSOD genes in stress tolerance and fruit development in watermelon.
关键词: abiotic stress / expression analysis / phylogeny / SOD / superoxide dismutase / watermelon
A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome
《医学前沿(英文)》 2023年 第17卷 第2期 页码 330-338 doi: 10.1007/s11684-022-0933-2
关键词: Clouston syndrome whole exome sequencing GJB6 gene novel variant unique phenotype
《医学前沿(英文)》 doi: 10.1007/s11684-023-1006-x
关键词: neurodevelopmental disorder autosomal recessive intellectual disability consanguinity spastic paraplegia hearing loss TMEM141
Genetic association between the polymorphism of cytosolic PLA2 gene family and schizophrenia
Qiong YU PhD, Xiang-Fei MENG PhD, Jie-Ping SHI, Ya-Qin YU PhD,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 101-105 doi: 10.1007/s11684-010-0017-6
关键词: schizophrenia cytosolic phospholipase A2 ligase detection reaction polymorphism
《农业科学与工程前沿(英文)》 2021年 第8卷 第2期
Late embryogenesis abundant (LEA) genes encode highly hydrophilic proteins that are essential in abiotic stress responses. However, most LEA genes in higher plants have not yet been investigated. This study identified an LEA family gene (PtrLEA7) from Poncirus trifoliata and studied its function in drought tolerance. The full-length coding sequence of PtrLEA7 was 420 bp encoding a protein of 139 amino acids. Phylogenetic analysis shows that PtrLEA7 protein belongs to the LEA_4 subfamily. Expression profiling by qPCR found that PtrLEA7 was strongly induced by dehydration, cold and ABA treatments, and slightly induced by salt stress. Subcellular localization reveals that PtrLEA7 protein was located in both cytoplasm and nucleus. To investigate its function, transgenic plants of both tobacco and Poncirus trifoliata overexpressing PtrLEA7 were obtained. Stress tolerance assays show that overexpression lines had enhanced dehydration and drought tolerance compared with wild type plants, indicating that PtrLEA7 positively regulates drought tolerance. In addition, transgenic plants had much higher expression levels of three antioxidant enzyme genes (CAT, SOD and POD) and significantly increased catalase enzyme activity, accompanied by reduced reactive oxygen species accumulation in comparison with wild type plants. Collectively, this study demonstrates that PtrLEA7 can confer enhanced drought tolerance partially via enhancing antioxidant capacity.
Guizhong XIE, Fenglin ZHOU, Hao LI, Xiaoyu WEN, Fannian MENG
《机械工程前沿(英文)》 2019年 第14卷 第3期 页码 332-341 doi: 10.1007/s11465-019-0540-3
关键词: Taylor expansion crack front elements stress intensity factors dual boundary element method
SUPEROXIDE DISMUTASE FAMILY GENES IN WATERMELON AND THEIR RESPONSES TO DIFFERENT ABIOTIC STRESSES
Yong ZHOU, Linjuan OUYANG, Dahu ZHOU, Yicong CAI, Haohua HE
《农业科学与工程前沿(英文)》 2021年 第8卷 第4期 页码 645-658 doi: 10.15302/J-FASE-2020350
关键词: abiotic stress expression analysis phylogeny SOD superoxide dismutase watermelon
钟慧玲
《中国工程科学》 2014年 第16卷 第5期 页码 31-33
文本研究人流后关爱(PAC)在人工流产术后计划生育关爱中的应用。选择2011年1月—2013年1月,武汉市蔡甸区计划生育服务站门诊进行人工流产的260 名病例为分析对象,根据其先后序号按照奇偶顺序分为关爱PAC组和对照组,每组130 例,对PAC组进行流产后关爱指导,而对照组只进行常规处理。一年后,共收回有效问卷248 份,其中关爱组126 份,对照组122 份。PAC组避孕知识和人流后保健知识掌握优良率均高于对照组,生活质量评分有明显优势,而重复流产率明显较低,育龄妇女满意率较高。其差异均有统计学意义(P<0.05)。高价值的PAC关爱,对于减少重复流产的概率和提高生活质量有着积极重要的意义。
Combination of western medicine and Chinese traditional patent medicine in treating a family case of
Li Ni, Ling Zhou, Min Zhou, Jianping Zhao, Dao Wen Wang
《医学前沿(英文)》 2020年 第14卷 第2期 页码 210-214 doi: 10.1007/s11684-020-0757-x
关键词: novel coronavirus (2019-nCoV) COVID-19 Chinese traditional patent medicine Shuanghuanglian oral liquid
《医学前沿(英文)》 2023年 第17卷 第4期 页码 685-698 doi: 10.1007/s11684-022-0942-1
关键词: acute myeloid leukemia acyl-CoA synthetase long chain family member 5 Wnt3a palmitoylation ABT-199
标题 作者 时间 类型 操作
Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic
期刊论文
SUPEROXIDE DISMUTASE FAMILY GENES IN WATERMELON AND THEIR RESPONSES TO DIFFERENT ABIOTIC STRESSES
期刊论文
A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome
期刊论文
Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function
期刊论文
Genetic association between the polymorphism of cytosolic PLA2 gene family and schizophrenia
Qiong YU PhD, Xiang-Fei MENG PhD, Jie-Ping SHI, Ya-Qin YU PhD,
期刊论文
OVEREXPRESSION OF PTRLEA7, A LATE EMBRYOGENESIS ABUNDANT FAMILY GENE FROM PONCIRUS TRIFOLIATA, CONFERS
期刊论文
A family of non-conforming crack front elements of quadrilateral and triangular types for 3D crack problems
Guizhong XIE, Fenglin ZHOU, Hao LI, Xiaoyu WEN, Fannian MENG
期刊论文
SUPEROXIDE DISMUTASE FAMILY GENES IN WATERMELON AND THEIR RESPONSES TO DIFFERENT ABIOTIC STRESSES
Yong ZHOU, Linjuan OUYANG, Dahu ZHOU, Yicong CAI, Haohua HE
期刊论文
Combination of western medicine and Chinese traditional patent medicine in treating a family case of
Li Ni, Ling Zhou, Min Zhou, Jianping Zhao, Dao Wen Wang
期刊论文